Sciencebiotech
Blue-light labeling uncovers unexpected protein partners of G4 DNA
DNA structures known as G-quadruplexes (G4) are complex, four-stranded bundles that play a critical role in gene regulation. Researchers have developed a new method using blue-light labeling to identify the specific proteins that interact with these structures. This breakthrough allows scientists to map how G4 structures influence gene expression across the genome. By identifying these protein partners, the study provides new insights into how cells control genetic activity at the molecular level.