Sciencebiotech
3D-printed inserts enable new light sheet microscopy method
Researchers at Rice University have developed a novel method utilizing 3D-printed inserts to adapt single-objective light sheet microscopy for standard commercial sample chambers. This advancement allows biologists to achieve high-contrast imaging while minimizing photodamage and photobleaching in biological samples. Published in Nano Letters, the technique by Anna-Karin Gustavsson expands the accessibility and usability of advanced light sheet microscopy. By working within existing commercial hardware, it bridges the gap between specialized custom setups and routine laboratory workflows.